Anthony Guiseppi-Elie, Sc.D. -- Research Activities

Current Research in Bioengineering

The Guiseppi group is focused on basic, applied and development research of engineered biosystems in the service of human health. This informs broad interest at the confluence of materials and surfaces, devices and instruments, molecular and cell biology, and signal processing. The group is project-oriented with an emphasis on deliverable systems for clinical deployment.

Current Research in Chemical and Biomolecular Engineering

Electronic-NOSE for Monitoring of the Expired Breath During Trauma

Odors are molecules of chemicals carried in the air. An engineering challenge is to develop a sensing system capable of detecting trace amounts of chemicals that are associated with a particular class of odors. The electronic NOSE (Natural Olfactory Sensor Emulator™) platform project investigates the use of a sensing system that is based on an array of chemically responsive organic thin film sensors along with an artificial neural network to distinguish specific chemicals within certain odors. An application of such an application of the e-NOSE is to determine the physiological status of trauma patients by monitoring their expired breath for volatile organic compounds.

Bioelectrochemistry Using Carbon Nanotubes

Advances in nanotechnology have yielded materials with engineering properties that allow the development of nanobiosensors. Incorporating nanoscale materials into biosensors and bioprobes allows researchers to directly monitor and measure biochemical activity at the sub-cellular level. We are investigating the use of carbon nanotubes in nanobiosensor designs with the goal of directly measuring and controlling redox enzyme kinetics. Eliminating the need for reagents such as oxygen will greatly improve the performance of in vivo nanobiosensors that must operate under anaerobic or hypoxic conditions.

Bio-Active and Bio-Smart Polymers
We have been concerned with the synthesis, characterization and application of polymeric materials for bio-technical applications. Amongst these interests are; i) biocompatible, biorecognition layers of implantable electronic devices exemplified by biosensors for glucose and lactate used in diagnostics, ii) environmentally stimulated controlled release of bioactive molecules modulated by external biomarkers and exemplified by the production of an all-synthetic artificial pancreas capable of releasing insulin in response to changing levels of bathing glucose, and iii) arrays of chemo-resistive polymer devices responsive to gases and vapors exemplified by application to an electronic noses for the detection of odors.

Last Updated:April 18, 2009 -- Site Maintained by: Donna Kilbourne
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